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C-GEM also engages citizen scientists with a scientific discovery game, EteRNA, that introduces interested gamers to the key concepts of RNA structure, stability, and function.\r\n \r\nC-GEM’s research plan includes interrelated goals that will expand ribosome-mediated chemistry to generate molecular architectures unique in both structure and function. Novel experimental and computational tools to design, evolve, and characterize the molecules of translation will expand their chemical capacity in vitro and in vivo. The novel molecules and materials produced will probe the fundamental chemistry of peptides, impact human health and open new opportunities in bio-materials design. Education and participation programs integrate research, workforce development for biotechnology, and public engagement.\r\n\r\nThis award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.","activeAwd":"true","agency":"NSF","awardAgencyCode":"4900","awardee":"REGENTS OF THE UNIVERSITY OF CALIFORNIA, THE","awardeeAddress":"119 CALIFORNIA HALL","awardeeCity":"BERKELEY","awardeeCountryCode":"US","awardeeDistrict":"12","awardeeDistrictCode":"CA12","awardeeName":"University of California-Berkeley","awardeePhone":"5106433891","awardeeStateCode":"CA","awardeeZipCode":"947201509","cfdaNumber":"47.049","date":"08/14/2025","dirAbbr":"MPS","divAbbr":"CHE","estimatedTotalAmt":"18000000","expDate":"08/31/2030","fundAgencyCode":"4900","fundProgramName":"CHE CENTERS","fundsObligated":["FY 2025 = $3,000,000.00","FY 2026 = $2,850,000.00"],"fundsObligatedAmt":"5850000","histAwd":"false","id":"2503885","initAmendmentDate":"08/14/2025","jrnl":[{"artTitl":"Co-Translational Incorporation of (R)- and (S)-2-Hydroxy Acids In Vitro: A Structural and Biochemical Study on the E. coli Ribosome","auth":"Majumdar, Chandrima and Kent, Alexandra D and Hamlish, Noah X and Zhu, Cathy and Fitzgerald, Katelyn A and Cate, Jamie HD and Schepartz, Alanna","authIndCode":"N","dgtlObjId":"https://doi.org/10.1021/jacs.5c18603","jrnlTitl":"Journal of the American Chemical Society","jrnlVol":"148","jrnlYr":"2026","parPblcId":"10693144"},{"artTitl":"A family of archaeal hibernation factors that bind in tandem and protect ribosomes in dormant cells","auth":"Nissley, Amos J and Williams, Madison C and Shulgina, Yekaterina and Kivimae, Roan W and Nayak, Dipti D and Cate, Jamie_H D","authIndCode":"N","dgtlObjId":"https://doi.org/10.1038/s41467-026-74727-0","jrnlTitl":"Nature Communications","jrnlVol":"17","jrnlYr":"2026","parPblcId":"10706063"},{"artTitl":"Backbone extension acyl rearrangements edit cellular proteins to install -, - 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and -backbones~N~10693145~10693145~OSTI~2026-06-25 19:24:37.813","Journal of the American Chemical Society~2026~148~Soni, Chintan and Pressimone, Meghan and Nair, Malavika and Szalay, Kaitlyn and Hall, Matthew and Hamlish, Noah and Solivan, Alexander Carlos and Schepartz, Alanna and Chatterjee, Abhishek~https://doi.org/10.1021/jacs.5c18595~Co-Translational Incorporation of (R)- and (S)-2-Hydroxyacids In Vivo: Directed Evolution of Efficient Aminoacyl-tRNA Synthetases~N~10693142~10693142~OSTI~2026-06-29 19:21:07.146"],"startDate":"09/01/2025","title":"NSF Center for Genetically Encoded Materials","transType":"Cooperative Agreement","ueiNumber":"GS3YEVSS12N6"}],"metadata":{"offset":0,"rpp":25,"totalCount":1}}}